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Division of Signaling and Gene Expression at the La Jolla Institute for Immunology

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    • Regulation of NFAT and NFkB
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Category: Research

A cancer without a cause

March 10, 2021April 29, 2022Research

Testing for breast and ovarian cancers has come a long way—but at-risk patients still fall through the cracks. LJI scientist Anup Kumar Singh has won funding to learn more about cancer-causing mutations. Anup Kumar Singh, Ph.D., a postdoctoral fellow at […]

LJI researchers reveal unexpected versatility of an ancient DNA repair factor

December 2, 2019April 29, 2022Research

LA JOLLA, CA—If a bone breaks or a tendon snaps, you know to seek treatment immediately. But your most fragile and precious cellular commodity, chromosomal DNA, breaks with astounding frequency—some estimate as many as 10,000 times a day per cell—usually […]

TET proteins: double agents in DNA methylation prevent catastrophic cancer

July 30, 2019April 29, 2022Research

LA JOLLA, CA—In addition to the four major bases in the DNA alphabet – A, C, G and T – there is also a minor “fifth” base, 5-methylcytosine (5mC), which plays a disproportionately important role in deciding whether genes and […]

TET gene mutations in T regulatory cells unleash fatal autoimmune disease in mice

May 7, 2019June 25, 2019Research

May 1, 2019 // Nature Communications New study reveals how a subset of T cells morphs from peacemaker to rabble-rouser when TET activity is lost LA JOLLA, CA—A subtype of T cells called T regulatory cells are major players in […]

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