LA JOLLA, CA—If a bone breaks or a tendon snaps, you know to seek treatment immediately. But your most fragile and precious cellular commodity, chromosomal DNA, breaks with astounding frequency—some estimate as many as 10,000 times a day per cell—usually […]

LA JOLLA, CA—In addition to the four major bases in the DNA alphabet – A, C, G and T – there is also a minor “fifth” base, 5-methylcytosine (5mC), which plays a disproportionately important role in deciding whether genes and […]

May 1, 2019 // Nature Communications New study reveals how a subset of T cells morphs from peacemaker to rabble-rouser when TET activity is lost LA JOLLA, CA—A subtype of T cells called T regulatory cells are major players in […]

Apr 26, 2019 // Science Immunology New study sheds light on what goes awry in malignancies marked by TET mutation LA JOLLA, CA—A family of TET proteins regulates gene expression in many cell types by influencing chromosome structure. TET proteins […]