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Division of Signaling and Gene Expression at the La Jolla Institute for Immunology

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    • Regulation of NFAT and NFkB
    • Store-Operated Calcium Entry
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    • Regulation of gene expression in T and B cells
    • TET family of DNA methylcytosine oxidases
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Scientists devise strategies to counteract T Cell exhaustion in CAR T cancer therapies

May 7, 2019June 25, 2019Research

Feb 27, 2019 La Jolla Institute scientists show that deleting troublesome proteins in a mouse model can shrink tumors and prolong survival. LA JOLLA, CA – A growing number of cancer patients are being offered a promising new treatment called […]

La Jolla Institute Receives $ 4.5 Mill Cancer Moonshot Award

May 7, 2019June 25, 2019Research

Oct 18, 2018 The grant will help improve existing immunotherapeutic options; accelerate the development of novel cancer vaccines and personalized therapies for the treatment of head and neck cancer LA JOLLA, CA—Researchers at La Jolla Institute for Immunology (LJI) and UC San […]

Hugo Sepulveda named PEW Latin American Fellow in Biomedical Sciences

August 13, 2018June 25, 2019Research

Hugo Sepúlveda receives prestigious fellowship in recognition of his innovative research LA JOLLA, CA— June 14, 2018 Postdoctoral researcher Hugo Sepúlveda, Ph.D., has been named a 2018 Pew Latin American Fellow in Biomedical Sciences, the Pew Charitable Trust announced today. […]

The molecular underpinnings of T cell exhaustion

August 13, 2018June 25, 2019Research

LA JOLLA, CA— March 14, 2017 One reason we survive into adulthood is that cell-killing T cells usually recognize and eliminate cancerous or pathogen-infected cells. But prolonged overactivity of immune cells summoned to a tumor or infection site can render […]

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